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Page 1
Ion channel TRPV2 is critical in enhancing B cell activation and function.
Li C, Zhao M, Liu X, Li Y, Xu B, Zhou L, Sun X, Sun W, Kang N, Ji Z, Li T, An H, Wang F, Wu C, Ye JY, Zhang JR, Wang Q, Zhao X, Li Z, Liu W. Li C, et al. J Exp Med. 2024 Mar 4;221(3):e20221042. doi: 10.1084/jem.20221042. Epub 2024 Feb 14. J Exp Med. 2024. PMID: 38353705
Physiologically, TRPV2 expression level is positively correlated to influenza-specific antibody production and is low in newborns and seniors. ...Correspondingly, mice with deficient TRPV2 in B cells display impaired antibody responses following immunization. ...
Physiologically, TRPV2 expression level is positively correlated to influenza-specific antibody production and is low in newborns and …
Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease.
Robbins N, Koch SE, Rubinstein J. Robbins N, et al. Transl Res. 2013 Jun;161(6):469-76. doi: 10.1016/j.trsl.2013.02.003. Epub 2013 Feb 27. Transl Res. 2013. PMID: 23453732 Review.
Activation of peripheral TRPV1 via painful stimuli or capsaicin has been shown to have cardioprotective effects, whereas genetic abrogation of TRPV1 results in increased myocardial damage after ischemia and reperfusion injury in comparison to wild-type mice. Furthermore, blood
Activation of peripheral TRPV1 via painful stimuli or capsaicin has been shown to have cardioprotective effects, whereas genetic abrogation …
Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats.
O'Hare M, Esquiva G, McGahon MK, Hombrebueno JMR, Augustine J, Canning P, Edgar KS, Barabas P, Friedel T, Cincolà P, Henry J, Mayne K, Ferrin H, Stitt AW, Lyons TJ, Brazil DP, Grieve DJ, McGeown JG, Curtis TM. O'Hare M, et al. JCI Insight. 2022 Sep 22;7(18):e155128. doi: 10.1172/jci.insight.155128. JCI Insight. 2022. PMID: 36134661 Free PMC article.
Retinal blood flow autoregulation is mediated by the myogenic response of the retinal arterial vessels, a process that is initiated by the stretch-dependent activation of TRPV2 channels on the retinal vascular smooth muscle cells (VSMCs). ...We also demonstrate that …
Retinal blood flow autoregulation is mediated by the myogenic response of the retinal arterial vessels, a process that is initiated b …
Distribution of CGRP and TRPV2 in Human Paranasal Sinuses.
Sato T, Sasahara N, Kanda N, Sasaki Y, Yamaguma Y, Kokubun S, Yajima T, Ichikawa H. Sato T, et al. Cells Tissues Organs. 2017;203(1):55-64. doi: 10.1159/000448074. Epub 2016 Aug 24. Cells Tissues Organs. 2017. PMID: 27553072
CGRP-IR nerve fibers were common in the maxillary sinus whereas TRPV2-IR nerve fibers were abundant in the ethmoid sinus. They were located around large blood vessels in the lamina propria. ...In the human trigeminal ganglion (TG), sensory neurons contained CGRP or …
CGRP-IR nerve fibers were common in the maxillary sinus whereas TRPV2-IR nerve fibers were abundant in the ethmoid sinus. They were l …
Downregulated Expression of TRPV2 in Peripheral Blood Cells following Acute Myocardial Infarction Is Inversely Correlated with Serum Levels of CRP and Troponin I.
Rozenbaum Z, Cohen L, Bigelman E, Shacham Y, Keren G, Entin-Meer M. Rozenbaum Z, et al. Cardiology. 2018;139(3):169-174. doi: 10.1159/000486530. Epub 2018 Jan 26. Cardiology. 2018. PMID: 29393104
METHODS: Patients who underwent coronary angiography due to AMI or chest pain were prospectively included. PBMCs were isolated from whole blood by Ficoll gradient centrifugation. TRPV2 expression was analyzed by real-time PCR. ...CONCLUSIONS: We assume that peripher …
METHODS: Patients who underwent coronary angiography due to AMI or chest pain were prospectively included. PBMCs were isolated from whole …
Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood.
Saunders CI, Kunde DA, Crawford A, Geraghty DP. Saunders CI, et al. Mol Immunol. 2007 Feb;44(6):1429-35. doi: 10.1016/j.molimm.2006.04.027. Epub 2006 Jun 14. Mol Immunol. 2007. PMID: 16777226
The vanilloid receptor family of cation channels includes the capsaicin-sensitive, proton- and heat-activated TRPV1 and noxious heat-activated TRPV2. The present study demonstrates both gene and protein expression of TRPV1 and TRPV2 in human peripheral blood
The vanilloid receptor family of cation channels includes the capsaicin-sensitive, proton- and heat-activated TRPV1 and noxious heat-activat …
Cannabidiol: Influence on B Cells, Peripheral Blood Mononuclear Cells, and Peripheral Blood Mononuclear Cell/Rheumatoid Arthritis Synovial Fibroblast Cocultures.
Lowin T, Laaser SA, Kok C, Bruneau E, Pongratz G. Lowin T, et al. Cannabis Cannabinoid Res. 2023 Apr;8(2):321-334. doi: 10.1089/can.2021.0241. Epub 2022 Aug 3. Cannabis Cannabinoid Res. 2023. PMID: 35920857
In this study, we elucidate the effects of CBD on B cells and peripheral blood mononuclear cells (PBMCs) in respect to survival, calcium mobilization, drug uptake, and cytokine (IL-6, IL-10, and TNF) and immunoglobulin production. ...Results: B cells express two major targ …
In this study, we elucidate the effects of CBD on B cells and peripheral blood mononuclear cells (PBMCs) in respect to survival, calc …
Transient receptor potential channels in multiple myeloma.
Meng L, Gu G, Bi L. Meng L, et al. Oncol Lett. 2022 Apr;23(4):108. doi: 10.3892/ol.2022.13228. Epub 2022 Feb 7. Oncol Lett. 2022. PMID: 35242236 Free PMC article. Review.
TRPV2 and TRPV4, that activate osteoclasts, contribute to the development of osteolytic bone disease caused by multiple myeloma. Both TRPV1 inhibition and TRPV2 activation synergize with bortezomib in the chemotherapy of multiple myeloma, and TRPC1 can determine the
TRPV2 and TRPV4, that activate osteoclasts, contribute to the development of osteolytic bone disease caused by multiple myeloma. Both
Predictive value of TRPV2 expression from peripheral blood mononuclear cells on the early recurrence of atrial fibrillation after radiofrequency catheter ablation.
Ling X, Wang J, Qin X, Lin C, Jie W, Chen Y, Fu D, Yang Y, Meng Q, Lin J, Liu H, Li T, Guo J. Ling X, et al. BMC Cardiovasc Disord. 2022 Dec 13;22(1):546. doi: 10.1186/s12872-022-02992-0. BMC Cardiovasc Disord. 2022. PMID: 36513971 Free PMC article.
We aimed to characterize the expression levels of TRPV2 mRNA in peripheral blood mononuclear cells (PBMCs) with/without early recurrence of atrial fibrillation (ERAF) after radiofrequency catheter ablation (RFCA), and to find a reliable predictor for ERAF. ...RESULT …
We aimed to characterize the expression levels of TRPV2 mRNA in peripheral blood mononuclear cells (PBMCs) with/without early …
75 results